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As of 2016, the population of the Baltimore metropolitan area was estimated to be just under 2.8 million, making it the 21st largest metropolitan area in the country.After a decline in major manufacturing, industrialization, and rail transportation, Baltimore shifted to a service-oriented economy, with Johns Hopkins Hospital (founded 1889) and Johns Hopkins University (founded 1876), now the city's top two employers.
With a population of 621,849 in 2015, Baltimore is the largest independent city in the United States.By 1820 its population had reached 60,000, and its economy had shifted from its base in tobacco plantations to sawmilling, shipbuilding, and textile production.These industries benefited from war but successfully shifted into infrastructure development during peacetime.Baltimore saw the first casualties of the war on April 19, 1861, when Union Soldiers en route from the President Street Station to Camden Yards clashed with a secessionist mob in the Pratt Street Riot.In the midst of the Long Depression which followed the Panic of 1873, the Baltimore & Ohio Railroad company attempted to lower its workers' wages, leading to strikes and riots in the city and beyond.The three settlements, covering 60 acres, became a commercial hub and in 1768 became the county seat.
Baltimore played a key part in events leading to and including the American Revolution. moved the city to join the resistance to British taxes, and merchants signed agreements to not trade with Britain.
and is home to some of the earliest National Register Historic Districts in the nation, including Fell's Point, Federal Hill, and Mount Vernon, which were added to the National Register between 1969–1971. The city has 66 National Register Historic Districts and 33 local historic districts. The Baltimore area had been inhabited by Native Americans since at least the 10th millennium BC, when Paleo-Indians first settled in the region.
Close to a third of the city's buildings (over 65,000) are designated as historic in the National Register, which is more than any other U. Over 65,000 properties are designated historic buildings in the National Register of Historic Places listings in Baltimore, more than any other U. One Paleo-Indian site and several Archaic period and Woodland period archaeological sites have been identified in Baltimore, including four from the Late Woodland period.
Harborplace, an urban retail and restaurant complex, opened on the waterfront in 1980, followed by the National Aquarium, Maryland's largest tourist destination, and the Baltimore Museum of Industry in 1981.
During the epidemic of HIV/AIDS in the United States, Baltimore City Health Department official Robert Mehl persuaded the city's mayor to form a committee to address food problems; the Baltimore-based charity Moveable Feast grew out of this initiative in 1990.
Soon after the city created the world's first dental college, the Baltimore College of Dental Surgery, in 1840, and shared in the world's first telegraph line, between Baltimore and Washington DC in 1844.